Healthcare

Jean Bennett - Developed first FDA approved gene therapy for humans

Jean Bennett - Developed first FDA approved gene therapy for humans

at Penn Medicine and a true pioneer in gene therapy research. Dr. Bennett led the team that developed the first FDA-approved gene therapy to treat inherited blindness, transforming the lives of patients with retinitis pigmentosa and other retinal diseases. Her groundbreaking work spans over three decades and has opened doors for gene therapy applications far beyond ophthalmology.

Dr. Bennett shares her remarkable journey from a curious child in New Haven, Connecticut—who chose seeds over candy at age four—to becoming a world-renowned scientist. She opens up about the challenges she faced as a woman in science, including being advised to leave her field entirely when seeking tenure at Penn. With candor and humor, she discusses how mentorship from previous Girl Power Gurus guest, Dr. Virginia Lee, helped her persevere, the emotional eureka moment when blind dogs first regained their sight, and what it felt like to witness blind children see for the first time. Dr. Bennett also offers invaluable advice for young women pursuing STEM careers, emphasizing the importance of finding work you love, building collaborative teams, and never giving up on your dreams despite the obstacles. This is a must-listen for anyone interested in science, medicine, or the power of determination.

Marianne Baernholdt - Dean UVA School of Nursing

Marianne Baernholdt - Dean UVA School of Nursing

This episode features Dr. Marianne Baernholdt, Dean of the School of Nursing at the University of Virginia, who brings a unique international perspective to healthcare leadership. Born in Denmark and educated across multiple countries, Dr. Baernholdt's journey spans continents, cultures, and nearly every role within the nursing profession.

We discuss her pioneering research in rural healthcare, which challenges common assumptions about healthcare quality in underserved areas. Her studies reveal that rural hospitals often excel in team dynamics and holistic patient care, providing crucial touchpoints for communities that would otherwise lack access to preventive healthcare. Dr. Baernholdt also shares insights from her global health work, including eye-opening experiences in South Africa where rural clinics demonstrated sophisticated quality tracking methods ahead of their time.

As an immigrant and first-generation college graduate, Dr. Baernholdt offers honest reflections on dealing with imposter syndrome, finding belonging in new environments, and learning to laugh at yourself along the way. Her advice to young women is refreshingly practical: be curious, don't limit yourself, and do it even when you're uncomfortable—because nobody else can see those butterflies in your stomach. From co-founding Denmark's first women's crisis center to leading a top nursing school while mentoring the next generation, Dr. Baernholdt exemplifies how embracing vulnerability and supporting others can create lasting change.